House and the team take on the case of a struggling artist (guest star Breckin Meyer) who has been painting bizarre portraits. Meanwhile, House auditions new best friends to replace Wilson, and soon uses Lucas for his own personal means to spy on Wilson and the other team members in the "Not Cancer" episode of House. House has hired Lucas (guest star Michael Weston), a private investigator, to dig up information about the deceased despite the team's skepticism.
As the team sorts through the records on the deceased donor recipients to find the common thread, they must deal with a new intrusion. With one already dying and the other healthy but sure to fall ill at any moment, the team must find out what was wrong with the original organ donor. When several people die suddenly and without warning five years after receiving transplants from a single organ donor, House and the team rush to save the only two surviving recipients. Meanwhile, Cutty attempts to salvage the irrepairable rift between House and WIlson, and Thirteen struggles to treat the patient objectively without bringing the reality of her own medical condition to the case. However, her shocking medical condition forces the team to rethink their initial diagnosis and see the case through House's eyes. The team suspects that the patient's symptoms stem from her obsession to constantly please her demanding boss. The team must push forward as they encounter a case involving an assistant to a high-profile executive, who is a textbook "Type A" personalitiy. He is forced to decide if House is a destructive force in his life, while House has to determine if he's responsible for the death of his best friend's girlfriend. Needing to make a change in his life and give himself time to recover emotionally, Wilson resigns from Princeton-Plainsboro. Eight weeks after the death of his girlfriend, Amber, Wilson is still mourning her death, and his relationship with his best friend House is shattered.
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